Abstract
The incidence and titer of ANCA were examined with 871 sera from patients with otorhinolaryngological diseases at our hospital. The cytoplasmic pattern of ANCA (c-ANCA) whose titer was more than 16 was detected only in the sera of patients with Wegener's granulomatosis (WG). The incidence of c-ANCA in active WG was more than 90%. The perinuclear staining pattern of ANCA (p-ANCA) was detected in almost 40% of patients with Sjögren's syndrome, 2.0% of inflammatory diseases and 1.0% of tumorous diseases. A high diagnostic value of c-ANCA in WG was found in patients with otorhinolaryngological diseases.
MeSH terms
-
Antibodies, Antineutrophil Cytoplasmic
-
Autoantibodies / analysis*
-
Biomarkers / analysis*
-
Cell Nucleus / immunology
-
Cell Nucleus / ultrastructure
-
Cytoplasm / immunology
-
Cytoplasm / ultrastructure
-
Fluorescent Antibody Technique
-
Gangrene
-
Granulomatosis with Polyangiitis / diagnosis
-
Granulomatosis with Polyangiitis / immunology
-
Humans
-
Neutrophils / immunology
-
Neutrophils / ultrastructure
-
Nose Diseases / diagnosis
-
Nose Diseases / immunology
-
Otorhinolaryngologic Diseases / blood
-
Otorhinolaryngologic Diseases / diagnosis*
-
Otorhinolaryngologic Diseases / immunology*
-
Otorhinolaryngologic Neoplasms / diagnosis
-
Otorhinolaryngologic Neoplasms / immunology
-
Sensitivity and Specificity
-
Sjogren's Syndrome / diagnosis
-
Sjogren's Syndrome / immunology
Substances
-
Antibodies, Antineutrophil Cytoplasmic
-
Autoantibodies
-
Biomarkers