Selection of Candida glabrata in pediatric bone marrow transplant recipients receiving fluconazole

Pediatr Hematol Oncol. 1994 Mar-Apr;11(2):207-10. doi: 10.3109/08880019409141658.

Abstract

We observed an alarmingly high rate (5/16 patients; 31.3%) of orointestinal colonization with Candida glabrata--often in high numbers--in pediatric bone marrow transplant recipients receiving fluconazole as antifungal prophylaxis. This selection is probably due to the intrinsically low susceptibility of C. glabrata to fluconazole.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Marrow Transplantation / adverse effects*
  • Candida / drug effects*
  • Child
  • Feces / microbiology
  • Female
  • Fluconazole / therapeutic use*
  • Humans
  • Infant
  • Longitudinal Studies
  • Male
  • Mouth / microbiology

Substances

  • Fluconazole