Primary rhabdomyosarcoma of the iliac bone in an adult: a case mimicking fibrosarcoma

Virchows Arch A Pathol Anat Histopathol. 1993;423(1):65-9. doi: 10.1007/BF01606434.

Abstract

Primary rhabdomyosarcoma of bone is exceedingly rare. We present a case of rhabdomyosarcoma of the iliac bone in a 32-year-old male. Histologically, the tumour consisted mainly of a uniform proliferation of elongated spindle cells arranged in a herring bone pattern, simulating fibrosarcoma. Focally there was a conventional embryonal pattern with scattered rhabdomyoblasts possessing an eosinophilic cytoplasm. Immunohistochemical studies disclosed expression of muscle markers such as desmin and muscle-specific actin, in both the embryonal and spindle-cell areas and myoglobin only in the embryonal areas. Such histological features are unusual for classical embryonal rhabdomyosarcoma. The anatomical site and age of the patient are also atypical.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antibodies, Monoclonal
  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / pathology
  • Diagnosis, Differential
  • Fibrosarcoma / diagnosis*
  • Humans
  • Ilium* / diagnostic imaging
  • Ilium* / pathology
  • Immunoenzyme Techniques
  • Male
  • Radiography
  • Rhabdomyosarcoma / diagnosis*
  • Rhabdomyosarcoma / diagnostic imaging
  • Rhabdomyosarcoma / pathology

Substances

  • Antibodies, Monoclonal