Abstract
Degeneration of the central white matter is described in old dogs. The presence of ubiquitin-immunoreactive free granules and intracytoplasmic globules in glial cells and macrophages, together with galacerebroside-immunoreactive precipitates and lipofusion storage, point to the likelihood of a primary myelin degeneration with deposits of non-degraded ubiquitin-protein conjugates and complex galactolipids.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aging / pathology*
-
Animals
-
Brain / pathology*
-
Dogs
-
Female
-
Galactosylceramides / immunology
-
Galactosylceramides / metabolism
-
Hippocampus / pathology
-
Immunohistochemistry
-
Lipofuscin / metabolism
-
Macrophages / ultrastructure
-
Male
-
Meninges / pathology
-
Microscopy, Immunoelectron
-
Nerve Degeneration / physiology
-
Neuroglia / ultrastructure
Substances
-
Galactosylceramides
-
Lipofuscin