Abstract
1. We investigated the effect of SA3443, a novel cyclic disulfide compound, on alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis in rats. 2. SA3443 given orally at doses of 100 or 300 mg/kg, three times at 4h intervals, dose-dependently suppressed the elevation of serum total bilirubin, alkaline phosphatase activity and transaminase activities induced by administration of ANIT (80 mg/kg) 3h before the second dosages of SA3443. 3. SA3443 also significantly inhibited the reduction of bile flow in the ANIT-treated rats. 4. These findings indicated that SA3443 had a markedly inhibitory effect on ANIT-induced intrahepatic cholestasis in rats.
MeSH terms
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1-Naphthylisothiocyanate / antagonists & inhibitors*
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Adjuvants, Immunologic / administration & dosage
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Adjuvants, Immunologic / pharmacology
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Alanine Transaminase / blood
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Alkaline Phosphatase / blood
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Animals
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Aspartate Aminotransferases / blood
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Azocines / administration & dosage
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Azocines / pharmacology*
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Bile / metabolism
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Bilirubin / blood
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Cholestasis, Intrahepatic / chemically induced
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Cholestasis, Intrahepatic / prevention & control*
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Disulfides / administration & dosage
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Disulfides / pharmacology*
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Male
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Rats
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Rats, Wistar
Substances
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Adjuvants, Immunologic
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Azocines
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Disulfides
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SA 3443
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1-Naphthylisothiocyanate
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Aspartate Aminotransferases
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Alanine Transaminase
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Alkaline Phosphatase
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Bilirubin