Simple sequence repeat length polymorphisms mapped to rat chromosome 11

Cytogenet Cell Genet. 1994;65(3):186-9. doi: 10.1159/000133629.

Abstract

Two genes and two anonymous DNA loci were mapped to rat chromosome 11 using F2 intercross progeny of Fischer (F344/N) and Lewis (LEW/N) inbred rats. These four loci formed a single linkage group covering 21.5 cM with the following map order: somatostatin (SST)-D11N161-D11N18-cell surface protein (MOX2). These four loci were typed by PCR-based simple sequence repeat (SSR) length polymorphism detection. For each marker four to seven different alleles were detected using a panel of 13 inbred rat strains (F344/N, LEW/N, BN/SsN, BUF/N, LER/N, MR/N, MNR/N, LOU/MN, ACI/N, WBB1/N, WBB2/N, SHR/N, WKY/N). Comparative gene mapping analysis suggests syntenic conservation between rat chromosome 11 and mouse Chromosome 16.

MeSH terms

  • Alleles
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • DNA Primers / chemistry
  • Genetic Linkage
  • Genetic Markers
  • Molecular Sequence Data
  • Polymorphism, Genetic
  • Rats
  • Rats, Inbred F344 / genetics*
  • Rats, Inbred Lew / genetics*
  • Repetitive Sequences, Nucleic Acid

Substances

  • DNA Primers
  • Genetic Markers