DNA adduct detection: some applications in monitoring exposure to environmental genotoxic chemicals

IARC Sci Publ. 1993:(124):373-8.

Abstract

In the assessment of genotoxic risk factors in the environment, the measurement of DNA adducts in aquatic organisms and in plants may have considerable implications. Using 32P-postlabelling, we have detected DNA adducts in the liver of carp (Chondrostoma nasus) from the River Rhône (France), both downstream and upstream from a polychlorinated biphenyl incineration plant. Some of the DNA adducts were specific to downstream fish, suggesting a differential pattern of exposure. We have also detected DNA damage in needles in a declining spruce forest. We found that, in the declining forest, the amounts of DNA adducts increase in relation to the degree of damage to the needles whereas, in a healthy forest, the levels of DNA adducts were low. We have also found DNA adducts in the leaves of hops grown in fields where heptachlor residues persisted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carps / metabolism
  • DNA / analysis*
  • DNA / drug effects
  • DNA Damage*
  • Environmental Monitoring / methods*
  • Female
  • Liver / chemistry
  • Male
  • Mutagens / toxicity*
  • Plants / chemistry
  • Trees / chemistry

Substances

  • Mutagens
  • DNA