3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

J Med Chem. 1993 Oct 15;36(21):3211-3. doi: 10.1021/jm00073a025.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Insulin / metabolism*
  • Insulin Secretion
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / metabolism*
  • Potassium Channels / drug effects*
  • Pyridines / chemical synthesis
  • Pyridines / chemistry
  • Pyridines / pharmacology*
  • Rats
  • Structure-Activity Relationship
  • Thiadiazines / chemical synthesis
  • Thiadiazines / chemistry
  • Thiadiazines / pharmacology*

Substances

  • Insulin
  • Potassium Channels
  • Pyridines
  • Thiadiazines