Abstract
A 25-year-old woman with acute lymphoblastic leukaemia, while in remission, developed paraparesis, with faecal and urinary incontinence. CT demonstrated increased density of the lumbar theca and enlargement of the nerve roots. Myelography showed complete obstruction below the L3 level. MRI showed increased signal intensity in the lumbar sac on T1 weighting, and the cauda equina enhanced with gadolinium-DTPA. Lymphoblasts were seen in the lumbar spinal fluid. After chemotherapy, these abnormalities resolved, as did the paraparesis and incontinence.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Combined Modality Therapy
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Female
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Humans
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Leukemic Infiltration / diagnosis*
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Leukemic Infiltration / drug therapy
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Leukemic Infiltration / pathology
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Leukemic Infiltration / radiotherapy
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Lumbar Vertebrae / pathology*
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Magnetic Resonance Imaging*
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Myelography*
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Neurologic Examination / drug effects
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Neurologic Examination / radiation effects
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
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Spinal Nerve Roots / pathology*
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Subarachnoid Space / pathology*
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Tomography, X-Ray Computed*