Abstract
beta A4, the principal constituent of the brain amyloid collections in Alzheimer's disease, is derived from a much larger precursor, the amyloid protein precursor (APP). APP exists in the blood as full-length, potentially amyloidogenic forms in platelets, and as an attenuated species in plasma and T-lymphocytes. Studies of circulating APP facilitate the elaboration of the function of this protein, as well as the elucidation of its processing in health and disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / blood
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Alzheimer Disease / metabolism
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Amyloid beta-Peptides / biosynthesis
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Amyloid beta-Peptides / blood*
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Amyloid beta-Protein Precursor / blood*
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Amyloid beta-Protein Precursor / metabolism
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Amyloidosis / metabolism
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Blood Platelets / metabolism
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Down Syndrome / metabolism
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Humans
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Lymphocytes / metabolism
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Protein Processing, Post-Translational
Substances
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor