Abstract
Fourteen mupirocin-resistant Staphylococcus aureus strains were isolated over 18 months; 12 exhibited low-level resistance, while two showed high-level resistance. Highly mupirocin-resistant strains contained a large plasmid which transferred mupirocin resistance to other S. aureus strains and to Staphylococcus epidermidis. This plasmid and pAM899-1, a self-transferable gentamicin resistance plasmid, have molecular and biologic similarities.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Conjugation, Genetic
-
DNA, Bacterial / isolation & purification
-
Drug Resistance, Microbial
-
Electrophoresis, Polyacrylamide Gel
-
Humans
-
Microbial Sensitivity Tests
-
Mupirocin / pharmacology*
-
Phenotype
-
Plasmids
-
Staphylococcal Infections / microbiology
-
Staphylococcus aureus / drug effects*
-
Staphylococcus aureus / genetics
-
Staphylococcus epidermidis / drug effects
-
Staphylococcus epidermidis / genetics