Abstract
Amphotericin B and fluconazole were compared for the treatment of experimental Candida endocarditis caused by Candida tropicalis and C. parapsilosis. Rabbits received no therapy, amphotericin B (1 mg/kg of body weight per day intravenously), or fluconazole (100 mg/kg/day intraperitoneally) for either 11 or 21 days. Against both species, amphotericin B and fluconazole were equally effective overall; however, amphotericin B was more rapidly fungicidal than fluconazole in vivo against C. tropicalis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / administration & dosage
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Amphotericin B / pharmacology
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Amphotericin B / therapeutic use*
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Animals
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Candida / drug effects
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Candidiasis / drug therapy*
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Candidiasis / microbiology
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Endocarditis / drug therapy*
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Endocarditis / microbiology
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Female
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Fluconazole / administration & dosage
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Fluconazole / pharmacology
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Fluconazole / therapeutic use*
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Heart / microbiology
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Injections, Intravenous
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Microbial Sensitivity Tests
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Rabbits
Substances
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Amphotericin B
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Fluconazole