Abstract
Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P < 0.0001) resulting in increased availability of long-chain fatty acids (P = 0.008) due to competitive valproate binding in the valproate-treated patients. The findings support a hypothesis on the pathogenesis of obesity as a complication of valproate treatment of epilepsy.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Body Mass Index
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Epilepsy / blood*
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Epilepsy / complications
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Epilepsy / drug therapy
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Fatty Acids, Nonesterified / blood
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Female
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Humans
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Male
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Middle Aged
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Models, Biological
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Obesity / blood*
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Obesity / complications
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Obesity / physiopathology
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Palmitic Acid
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Palmitic Acids / blood*
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Protein Binding
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Serum Albumin / metabolism*
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Valproic Acid / blood*
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Valproic Acid / therapeutic use*
Substances
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Fatty Acids, Nonesterified
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Palmitic Acids
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Serum Albumin
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Palmitic Acid
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Valproic Acid