[Fatal fulminant hepatitis induced by nilutamide (Anandron)]

P Pescatore; P Hammel; F Durand; P Bertheau; J Bernuau; D Huc; J L Gerbal; C Degott; J P Benhamou

[Fatal fulminant hepatitis induced by nilutamide (Anandron)]

Gastroenterol Clin Biol. 1993;17(6-7):499-501.

[Article in French]

Authors

P Pescatore¹, P Hammel, F Durand, P Bertheau, J Bernuau, D Huc, J L Gerbal, C Degott, J P Benhamou

Affiliation

¹ Service d'Hépatologie, Hôpital Beaujon, Clichy.

PMID: 8243938

Abstract

The first case of fatal fulminant hepatitis probably caused by nilutamide, a non steroidal antiandrogen derivative, is reported. Nilutamide administration had been continued for 6 days after the occurrence of jaundice, 52 days after beginning of treatment. The rapidly fatal outcome might have been promoted by coadministration of phenobarbital.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / drug therapy
Aged
Androgen Antagonists / adverse effects*
Androgen Antagonists / therapeutic use
Chemical and Drug Induced Liver Injury / etiology*
Chemical and Drug Induced Liver Injury / mortality
Chemical and Drug Induced Liver Injury / pathology
Drug Interactions
Humans
Imidazoles / adverse effects*
Imidazoles / therapeutic use
Imidazolidines*
Male
Phenobarbital / adverse effects
Prostatic Neoplasms / drug therapy

Substances

Androgen Antagonists
Imidazoles
Imidazolidines
nilutamide
Phenobarbital