Abstract
We have isolated a male-specific bovine genomic homologue of the human TSPY gene (testis-specific protein, Y-encoded). Two specific transcripts can be detected in bovine testicular RNA. The cloned sequence represents one copy of a clustered array of some 50-200 related sequences on the Y chromosome resembling the arrangement present in the human genome. The clone isolated from the bovine genome has two regions that are highly conserved between homo and bos. One stretch of DNA is homologous in 45 of 51 bp (88%), and the other stretch shares 71 of 100 bp (71%).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cattle
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Cell Cycle Proteins
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Cloning, Molecular
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DNA Probes
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DNA, Complementary / genetics
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DNA-Binding Proteins / genetics*
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Female
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Humans
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Male
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Molecular Sequence Data
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Nuclear Proteins*
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Polymerase Chain Reaction
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Sequence Homology, Nucleic Acid
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Sex-Determining Region Y Protein
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Species Specificity
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Testis / metabolism
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Transcription Factors*
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Y Chromosome*
Substances
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Cell Cycle Proteins
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DNA Probes
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DNA, Complementary
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DNA-Binding Proteins
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Nuclear Proteins
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Sex-Determining Region Y Protein
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TSPY1 protein, human
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Transcription Factors