Abstract
An immunosuppressive lectin was isolated from seed of Phaseolus vulgaris cv Cacahuate using physically entrapped stroma. The lectin was found to be a 94 kDa tetrameric protein. When 50 micrograms, of this lectin were administered intraperitoneally 2 days before the immunization with sheep red blood cells, humoral response against the immunogen was completely inhibited. Other properties of the protein are discussed.
MeSH terms
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Amino Acids / analysis
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Animals
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Carbohydrates / analysis
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Cattle
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Edetic Acid / pharmacology
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Erythrocytes / immunology
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Fabaceae*
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Goats
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Guinea Pigs
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Hemagglutination
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Humans
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Immunosuppression Therapy
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Immunosuppressive Agents*
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Macromolecular Substances
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Mice
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Molecular Weight
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Perissodactyla
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Phytohemagglutinins / chemistry
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Phytohemagglutinins / isolation & purification*
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Phytohemagglutinins / pharmacology
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Plant Lectins
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Plants, Medicinal*
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Rabbits
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Rats
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Seeds / chemistry*
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Sheep
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Temperature
Substances
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Amino Acids
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Carbohydrates
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Immunosuppressive Agents
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Macromolecular Substances
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Phytohemagglutinins
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Plant Lectins
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Edetic Acid