Abstract
A specialized region of the endoplasmic reticulum--the BFA body--is defined by the site of accumulation of coatomer when nonclathrin coat protein (COP)-coated vesicle assembly is prevented by the drug brefeldin A (BFA). BFA bodies are formed by part smooth, part rough domains of endoplasmic reticulum that are cis to the classical transitional endoplasmic reticulum and to BFA-induced Golgi remnants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brefeldin A
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Coatomer Protein
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Cyclopentanes / pharmacology*
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Endoplasmic Reticulum / ultrastructure*
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Golgi Apparatus / ultrastructure
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Immunohistochemistry
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Intracellular Membranes / ultrastructure
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Islets of Langerhans / ultrastructure
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Membrane Proteins / metabolism
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Microscopy, Electron
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Microtubule-Associated Proteins / metabolism
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Rats
Substances
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Coatomer Protein
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Cyclopentanes
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Membrane Proteins
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Microtubule-Associated Proteins
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Brefeldin A