Characterization of iturin A in antibiotics from various strains of Bacillus subtilis

J Antibiot (Tokyo). 1976 Oct;29(10):1043-9. doi: 10.7164/antibiotics.29.1043.

Abstract

Iturin A, an antifungal lipopeptide characterized by the presence of homologous liposoluble beta-aminoacids was found to be the active component to bacillomycin B, bacillomycin R and eumycin. Iturin A was identified by thin-layer chromatography, aminoacid analysis and by characterization of liposoluble aminoacids and peptides. Another two preparations: the antibiotic of Raubitschek and the bacillomycin of Landy et al. contain components of the same structural type but they are different from iturin A.

MeSH terms

  • Amino Acids / analysis
  • Antifungal Agents / analysis*
  • Antifungal Agents / biosynthesis
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Bacillus subtilis / metabolism*
  • Chemical Phenomena
  • Chemistry
  • Fungi / drug effects
  • Hydrolysis
  • Peptides / analysis
  • Peptides, Cyclic
  • Solubility

Substances

  • Amino Acids
  • Antifungal Agents
  • Peptides
  • Peptides, Cyclic
  • iturin A