Cardiff puerperal mood and hormone study. 1. Saliva steroid hormone profiles in late pregnancy and the puerperium: endocrine factors and parturition

Horm Res. 1993;39(3-4):138-45. doi: 10.1159/000182714.

Abstract

Participants were 120 primiparous women who had vaginal delivery of a non-handicapped child. Saliva was collected twice daily through parturition to day 35 post-partum. In the prepartum, a highly significant circadian rhythm was seen in cortisol, with a lower-amplitude rhythm in progesterone (AM/PM = 1.12). Evening samples showed a rise in cortisol, with a highly significant rise on day -1. The rise was small. The fall in progesterone in the 3 days before parturition was also small (approximately 6%). Neither change provides an obvious trigger for parturition.

MeSH terms

  • Adolescent
  • Adult
  • Affect*
  • Circadian Rhythm
  • Female
  • Humans
  • Hydrocortisone / metabolism*
  • Labor, Obstetric / physiology*
  • Postpartum Period / physiology*
  • Pregnancy
  • Progesterone / metabolism*
  • Saliva / metabolism*

Substances

  • Progesterone
  • Hydrocortisone