Abstract
The origin of the 0.1 Hz bursting of cultured rat cortical neurons in zero Mg2+ was studied by whole-cell recording, fluo-3 Ca2+ imaging, and multi-unit electrode array recording. A model is proposed in which spontaneous synaptic currents act as a random pacemaker.
MeSH terms
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Action Potentials / physiology
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Animals
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Calcium Channels / metabolism
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Cells, Cultured
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Cerebral Cortex / cytology
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Cerebral Cortex / physiology*
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Electrodes
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Electrophysiology
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Magnesium / physiology*
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Nerve Net / physiology*
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Neurons / physiology*
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Rats
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Receptors, N-Methyl-D-Aspartate / metabolism
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Synapses / physiology
Substances
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Calcium Channels
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Receptors, N-Methyl-D-Aspartate
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Magnesium