Cardiac synovial sarcoma with translocation (X;18) associated with asbestos exposure

C M Karn; M A Socinski; J A Fletcher; J M Corson; J E Craighead

doi:10.1002/1097-0142(19940101)73:1<74::aid-cncr2820730114>3.0.co;2-i

Cardiac synovial sarcoma with translocation (X;18) associated with asbestos exposure

Cancer. 1994 Jan 1;73(1):74-8. doi: 10.1002/1097-0142(19940101)73:1<74::aid-cncr2820730114>3.0.co;2-i.

Authors

C M Karn¹, M A Socinski, J A Fletcher, J M Corson, J E Craighead

Affiliation

¹ Department of Pathology, University of Vermont, Burlington 05405.

PMID: 8275440
DOI: 10.1002/1097-0142(19940101)73:1<74::aid-cncr2820730114>3.0.co;2-i

Abstract

A primary cardiac spindle cell tumor with immunoreactivity for keratin proteins is reported. Cytogenetic analysis of the tumor demonstrated a translocation (X;18), an aberration almost exclusively reported in synovial sarcomas. Postmortem examination revealed amphibole asbestos within the lungs and diaphragmatic pleural plaques indicative of asbestos exposure. These findings raise questions about the possible causation of this tumor.

Publication types

Case Reports

MeSH terms

Adult
Asbestos, Amosite*
Asbestos, Amphibole
Chromosome Aberrations / genetics
Chromosomes, Human, Pair 18*
Diaphragm / pathology
Heart Neoplasms / genetics*
Heart Neoplasms / pathology*
Humans
Lung / pathology
Male
Occupational Exposure*
Pleura / pathology
Sarcoma, Synovial / genetics*
Sarcoma, Synovial / pathology*
Translocation, Genetic / genetics*
X Chromosome*

Substances

Asbestos, Amphibole
Asbestos, Amosite
tremolite