Studies on the acetogenins of Formosan annonaceous plants. II. Cytotoxic acetogenins from Annona reticulata

F R Chang; Y C Wu; C Y Duh; S K Wang

doi:10.1021/np50100a005

Studies on the acetogenins of Formosan annonaceous plants. II. Cytotoxic acetogenins from Annona reticulata

J Nat Prod. 1993 Oct;56(10):1688-94. doi: 10.1021/np50100a005.

Authors

F R Chang¹, Y C Wu, C Y Duh, S K Wang

Affiliation

¹ Department of Microbiology, Kaohsiung Medical College, Taiwan, Republic of China.

PMID: 8277309
DOI: 10.1021/np50100a005

Abstract

Using cytotoxicity as a guide to fractionation, one novel acetogenin, annoreticuin-9-one [3], and four known cytotoxic acetogenins, squamone [4], solamin [5], annomonicin [6] and rolliniastatin 2 [7], were isolated from active extracts of the leaves of the Formosan plant Annona reticulata. Their structures were elucidated on the basis of uv, ir, 1H- and 13C-nmr, and ms data of the natural compounds and their derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Drug Screening Assays, Antitumor
Furans / isolation & purification*
Furans / pharmacology
Humans
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plants, Medicinal / chemistry*
Taiwan

Substances

Antineoplastic Agents, Phytogenic
Furans
Plant Extracts