Recurrent t(12;19)(q13;q13.3) in intracranial and extracranial hemangiopericytoma

W Henn; B Wullich; M Thönnes; W I Steudel; W Feiden; K D Zang

doi:10.1016/0165-4608(93)90022-e

Recurrent t(12;19)(q13;q13.3) in intracranial and extracranial hemangiopericytoma

Cancer Genet Cytogenet. 1993 Dec;71(2):151-4. doi: 10.1016/0165-4608(93)90022-e.

Authors

W Henn¹, B Wullich, M Thönnes, W I Steudel, W Feiden, K D Zang

Affiliation

¹ Institute of Human Genetics, University of the Saar, Homburg/Saar, Germany.

PMID: 8281520
DOI: 10.1016/0165-4608(93)90022-e

Abstract

We report on a recurrent intracranial hemangiopericytoma cytogenetically studied after short-term culture. The tumor had a uniform karyotype 47,XX,add(7)(q21),t(12;19)(q13;q13.3),del(13)(q14q22), +21. Remarkably, one case with an identical reciprocal (12;19) translocation has been previously reported as the sole cytogenetic change in a recurrent retroperitoneal hemangiopericytoma. This nonrandom structural change may characterize a subentity of hemangiopericytoma and might be of diagnostic value.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aneuploidy
Cerebellar Neoplasms / genetics*
Cerebellar Neoplasms / ultrastructure
Cerebellopontine Angle
Chromosome Aberrations
Chromosome Deletion
Chromosomes, Human, Pair 12 / ultrastructure*
Chromosomes, Human, Pair 19 / ultrastructure*
Female
Hemangiopericytoma / genetics*
Hemangiopericytoma / ultrastructure
Humans
Karyotyping
Middle Aged
Neoplasm Recurrence, Local / genetics
Retroperitoneal Neoplasms / genetics
Retroperitoneal Neoplasms / ultrastructure
Translocation, Genetic*