Abstract
Two new quinochalcone C-glycosides, hydroxysafflor yellow A (1a) and tinctormine (2a), were isolated from Carthamus tinctorius L. (Compositae) together with carthamin, safflor yellow B and safflomin C. The structures of 1a and 2a have been determined by spectroscopic methods including heteronuclear multiple-bond multiple-quantum coherence and linked scan FAB-MS. The latter compound (2a) was demonstrated to have potent Ca2+ antagonistic action.
MeSH terms
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Animals
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Calcium Channel Blockers / chemistry
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Calcium Channel Blockers / isolation & purification
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Calcium Channel Blockers / pharmacology*
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Chalcone / analogs & derivatives*
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Chalcone / chemistry
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Chalcone / isolation & purification
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Chalcone / pharmacology
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Dogs
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Heart Ventricles / drug effects
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Heart Ventricles / metabolism
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Pigments, Biological / chemistry
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Pigments, Biological / isolation & purification
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Pigments, Biological / pharmacology*
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Plants / chemistry*
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Quinones / chemistry
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Quinones / isolation & purification
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Quinones / pharmacology*
Substances
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Calcium Channel Blockers
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Pigments, Biological
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Quinones
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tinctormine
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hydroxysafflor yellow A
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Chalcone