Dauricoside, a new glycosidal alkaloid having an inhibitory activity against blood-platelet aggregation

S M Hu; S X Xu; X S Yao; C B Cui; Y Tezuka; T Kikuchi

doi:10.1248/cpb.41.1866

Dauricoside, a new glycosidal alkaloid having an inhibitory activity against blood-platelet aggregation

Chem Pharm Bull (Tokyo). 1993 Oct;41(10):1866-8. doi: 10.1248/cpb.41.1866.

Authors

S M Hu¹, S X Xu, X S Yao, C B Cui, Y Tezuka, T Kikuchi

Affiliation

¹ Shenyang College of Pharmacy, China.

PMID: 8281582
DOI: 10.1248/cpb.41.1866

Abstract

Dauricoside (1), a new glycosidal alkaloid, was isolated from the rhizomes of Menispermum dauricum DC. along with dauricine (2), daurisoline (3), dauriporphine (4), menisporphine (5), and 6-O-demethylmenisporphine (6), and its structure was determined by means of spectroscopic methods. Compounds 1, 2, and 3 inhibited blood-platelet aggregation induced by adenosine 5'-diphosphate (ADP).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / pharmacology*
Animals
Drugs, Chinese Herbal / chemistry*
Glucosides / chemistry
Glucosides / pharmacology*
Glycosides / chemistry
Glycosides / pharmacology*
Magnetic Resonance Spectroscopy
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / pharmacology*
Rabbits

Substances

Alkaloids
Drugs, Chinese Herbal
Glucosides
Glycosides
Platelet Aggregation Inhibitors
dauricoside