Abstract
In smooth muscle cells of the guinea-pig stomach fundus, transmural nerve stimulation evoked a cholinergic excitatory junction potential (e.j.p.) and, in the presence of atropine, a non-adrenergic non-cholinergic (NANC) inhibitory junction potential (i.j.p.). Suramin (> 10(-5) M), a putative inhibitor of the P2 purinoceptor, enhanced the e.j.p. amplitude and inhibited the i.j.p., with no significant effect on the membrane potential. Thus, a possible involvement of ATP in the generation of the NANC i.j.p. has to be considered.
MeSH terms
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Animals
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Autonomic Nervous System / drug effects
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Autonomic Nervous System / physiology*
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Electric Stimulation
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Gastric Fundus / drug effects*
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Gastric Fundus / innervation
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Gastric Fundus / physiology
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Guinea Pigs
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Male
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Membrane Potentials / drug effects
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Muscle, Smooth / drug effects*
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Muscle, Smooth / innervation
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Muscle, Smooth / physiology
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Neuromuscular Junction / drug effects*
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Receptors, Purinergic / drug effects
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Receptors, Purinergic / metabolism
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Suramin / pharmacology*
Substances
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Receptors, Purinergic
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Suramin