Relation of IL-2, IL-3 and IL-4 with allergic asthma induced by spores of mushroom (Pleurotus sapidus)

Biomed Environ Sci. 1993 Sep;6(3):281-5.

Abstract

The effects of IL-2, IL-3, and IL-4 activities on occurrence of allergic asthma induced by spores of mushroom have been studied by measuring the IL-2, IL-3, and IL-4 activities in culture supernatants of spleen lymphocytes from guinea pigs being stimulated with Con A. The IL-4 activity (14.9 +/- 0.18 u) in the culture supernatant was higher than control group (6.7 +/- 1.5 u). The IL-2 and IL-3 activities were all similar to that of the control group. The IL-4 synthesis was similarly raised as the IL-4 activity. These results indicated that there is a relationship between the occurrence of allergic asthma and the increase of IL-4.

MeSH terms

  • Animals
  • Asthma / etiology
  • Asthma / metabolism*
  • Cells, Cultured
  • Concanavalin A / pharmacology
  • Guinea Pigs
  • Hypersensitivity / etiology
  • Hypersensitivity / metabolism*
  • Interleukin-2 / biosynthesis
  • Interleukin-2 / metabolism*
  • Interleukin-3 / biosynthesis
  • Interleukin-3 / metabolism*
  • Interleukin-4 / biosynthesis
  • Interleukin-4 / metabolism*
  • Lymphocytes / metabolism
  • Mice
  • Polyporaceae*
  • Reference Values
  • Spleen / cytology
  • Spleen / metabolism
  • Spores, Fungal
  • Tumor Cells, Cultured

Substances

  • Interleukin-2
  • Interleukin-3
  • Concanavalin A
  • Interleukin-4