Antineutrophil antibodies in inflammatory bowel disease recognize different antigens

A H Mulder; J Broekroelofs; G Horst; P C Limburg; G F Nelis; C G Kallenberg

doi:10.1007/978-1-4757-9182-2_94

Antineutrophil antibodies in inflammatory bowel disease recognize different antigens

Adv Exp Med Biol. 1993:336:519-22. doi: 10.1007/978-1-4757-9182-2_94.

Authors

A H Mulder¹, J Broekroelofs, G Horst, P C Limburg, G F Nelis, C G Kallenberg

Affiliation

¹ Dept. of Clinical Immunology, University Hospital Groningen, The Netherlands.

PMID: 8296668
DOI: 10.1007/978-1-4757-9182-2_94

Abstract

Anti-neutrophil cytoplasmic antibodies (ANCA) were observed in 31 out of 68 sera (45%) from Ulcerative Colitis (UC) patients and in 13 out of 38 Crohn's Disease (CD) sera (34%). The presence of ANCA was not related to disease activity, nor to the localization of the disease manifestations. By Western Blotting ANCA showed reactivity with either lactoferrin, polypeptides occurring as a doublet of 66/67 kD MW, or polypeptides occurring as a doublet of 63/54 kD MW.

MeSH terms

Antibodies, Antineutrophil Cytoplasmic
Antibody Specificity*
Autoantibodies / blood
Autoantibodies / immunology*
Autoantigens / immunology*
Blotting, Western
Colitis, Ulcerative / immunology
Crohn Disease / immunology
Humans
Immunoglobulin G / blood
Immunoglobulin G / immunology*
Inflammatory Bowel Diseases / immunology*
Lactoferrin / immunology

Substances

Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Autoantigens
Immunoglobulin G
Lactoferrin