Abstract
We studied IgG subclass distribution of ANCA in 247 patients with ELISA. We used monoclonal subclass specific antibodies and purified MPO and proteinase 3 as antigen. We found that IgG1 and IgG4 yield high values in both groups. We also found that high IgG2 titers were rare among the anti-proteinase 3 positive, while it was common among anti-MPO sera. In the assays for IgG3 the situation was the opposite.
MeSH terms
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Antibodies, Antineutrophil Cytoplasmic
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Antibodies, Monoclonal
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Antigens / immunology
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Autoantibodies / blood*
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Immunoglobulin G / blood*
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Male
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Middle Aged
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Myeloblastin
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Peroxidase / immunology
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Serine Endopeptidases / immunology
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Vasculitis / immunology
Substances
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Antibodies, Antineutrophil Cytoplasmic
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Antibodies, Monoclonal
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Antigens
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Autoantibodies
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Immunoglobulin G
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Peroxidase
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Serine Endopeptidases
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Myeloblastin