Abstract
5-Hydroxytryptamine increases transmucosal short-circuit current across human isolated small intestinal mucosa. The competitive 5-HT4 antagonist, DAU 6285 evoked a concentration-dependent, dextral and parallel shift of the concentration-response curve to 5-HT, with no alteration of the maximum response. Schild analysis of this antagonism produced a Schild regression with a slope of 1.00 and an apparent pA2 estimate of 6.17. It appears that a 5-HT4 receptor may mediate the short-circuit current response of human small intestinal mucosa to 5-HT.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzimidazoles / pharmacology
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Bridged Bicyclo Compounds / pharmacology
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Bridged Bicyclo Compounds, Heterocyclic*
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Electrophysiology
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Humans
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In Vitro Techniques
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Intestinal Mucosa / drug effects
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Intestinal Mucosa / metabolism*
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Intestinal Mucosa / physiology
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Intestine, Small / drug effects*
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Intestine, Small / metabolism*
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Intestine, Small / ultrastructure
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Receptors, Serotonin / classification
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Receptors, Serotonin / physiology*
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Serotonin / pharmacology*
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Serotonin Antagonists / pharmacology
Substances
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Benzimidazoles
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Bridged Bicyclo Compounds
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Bridged Bicyclo Compounds, Heterocyclic
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Receptors, Serotonin
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Serotonin Antagonists
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DAU 6285
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Serotonin