Abstract
The 30-kDa protein (P32) is a mycobacterial secreted antigen which is homologous in Mycobacterium bovis and M. tuberculosis. In vitro, P32 induced T-cell proliferation. M. tuberculosis- or P32-stimulated T-cell lines lysed macrophages pulsed with P32 or M. tuberculosis, respectively. We conclude that P32 stimulates cytotoxic T cells specifically.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Bacterial / chemistry
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Antigens, Bacterial / immunology*
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BCG Vaccine / immunology
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BCG Vaccine / isolation & purification
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Bacterial Proteins / chemistry
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Bacterial Proteins / immunology*
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Humans
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In Vitro Techniques
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Lymphocyte Activation
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Macrophages / immunology
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Molecular Weight
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Mycobacterium bovis / immunology*
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Antigens, Bacterial
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BCG Vaccine
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Bacterial Proteins
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antigen 85, Mycobacterium bovis