Histomorphometric findings at the study of marrow puncture specimens were compared to sonographic picture of the liver and spleen in 20 myeloid leukemia chronic. Histomorphometric and sonographic changes observed showed parallel pathological processes in the hemopoietic micro-surroundings and in the liver, spleen. Sonography proved able to considerably broaden diagnostic armory of the physician, to prognosticate leukemia outcomes, thus suggesting a differential approach to the disease treatment.