Abstract
Of 169 children with retinoblastoma treated at our institution between 1962 and 1993, 5 had concurrent severe mental retardation, hypotonia, and abnormalities of constitutional chromosome 13. The associated skeletal abnormalities of these 5 children are described and include delayed skeletal maturation, metaphyseal abnormalities, microcrania, facial bone abnormalities, and gracile long bones.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Abnormalities, Multiple / diagnostic imaging*
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Bone and Bones / diagnostic imaging
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Child, Preschool
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Chromosome Aberrations / diagnostic imaging*
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Chromosome Disorders
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Chromosomes, Human, Pair 13*
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Eye Neoplasms / complications
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Eye Neoplasms / genetics
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Female
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Humans
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Infant
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Male
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Radiography
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Retinoblastoma / complications
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Retinoblastoma / genetics
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Syndrome