Abstract
A double-blind group comparison study of L-sulpiride and amitriptyline was carried out in 30 bipolar outpatients on maintenance treatment with lithium suffering from a major depressive recurrence. L-sulpiride showed equivalent antidepressant activity to amitriptyline at 4 weeks using the Hamilton Rating Scale for Depression. However, the onset of action was faster in the L-sulpiride group, showing a significant improvement at 1 week in both anxiety-somatization and specific depression items, including depressed mood, feelings of guilt, work & activities and retardation. The incidence of anticholinergic side effects was significantly higher in the amitriptyline treatment group.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Ambulatory Care
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Amitriptyline / administration & dosage
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Amitriptyline / adverse effects
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Amitriptyline / therapeutic use*
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Bipolar Disorder / drug therapy*
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Bipolar Disorder / psychology
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Constipation / chemically induced
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Double-Blind Method
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Drug Administration Schedule
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Drug Therapy, Combination
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Female
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Humans
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Lithium / therapeutic use*
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Male
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Middle Aged
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Personality Inventory
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Psychiatric Status Rating Scales
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Sleep Stages
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Sulpiride / administration & dosage
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Sulpiride / adverse effects
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Sulpiride / therapeutic use*
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Tremor / chemically induced
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Xerostomia / chemically induced
Substances
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Amitriptyline
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Sulpiride
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Lithium