Abstract
A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Apolipoprotein A-I / genetics*
-
Computer Simulation*
-
Female
-
Genetic Linkage
-
Genetic Predisposition to Disease
-
Humans
-
Likelihood Functions
-
Lipoproteins, HDL / classification
-
Lipoproteins, HDL / genetics*
-
Male
-
Models, Genetic*
-
Models, Statistical
-
Multivariate Analysis
-
Phenotype
Substances
-
Apolipoprotein A-I
-
Lipoproteins, HDL