Short communication: adverse chronic effects of high-dose irradiation on proximal bronchus in patients treated for bronchogenic carcinoma

Br J Radiol. 1993 May;66(785):477-9. doi: 10.1259/0007-1285-66-785-477.

Abstract

Of five patients with epidermoid carcinoma of the lung who were treated with small fields of 80 Gy in 40 fractions/8-11 weeks (TDF123-129) to the hilar region, four patients developed marked stenosis of the proximal bronchi without tumour progression and died of pulmonary insufficiency 1-3 years after radiotherapy. These results should serve as a warning against escalation of the radiation dose, and the upper optimal dose might prove to be less than 80 Gy for the treatment of pulmonary hilar lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bronchi / radiation effects*
  • Bronchoconstriction
  • Carcinoma, Bronchogenic / radiotherapy*
  • Female
  • Humans
  • Lung Neoplasms / radiotherapy*
  • Male
  • Radiotherapy Dosage*
  • Respiratory Insufficiency / etiology