Abstract
The efficacy of bronchodilator nebuliser solutions may be influenced by the presence of preservatives. In a double blind, randomised, crossover study the effect of preservatives in determining the airway responses to 5 mg of terbutaline was studied in a group of 21 atopic asthmatic patients. The presence of preservatives affected neither the bronchodilator action of terbutaline nor its protection against bronchoconstriction induced by histamine.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Inhalation
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Adult
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Asthma / drug therapy*
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Bronchoconstriction / drug effects
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Double-Blind Method
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Female
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Forced Expiratory Volume / drug effects
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Histamine
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Humans
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Male
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Nebulizers and Vaporizers
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Preservatives, Pharmaceutical / pharmacology*
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Terbutaline / administration & dosage*
Substances
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Preservatives, Pharmaceutical
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Histamine
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Terbutaline