Abstract
We have isolated a full-size cDNA coding for cardiac troponin T (cTnT) from a human adult heart library, using a slow skeletal TnT probe. This cDNA detected a 1.2 kb mRNA in fetal and post-natal human heart, the amount of which increased during ontogenic development. Interestingly, a similar transcript was coexpressed in fetal skeletal muscle, together with the 0.9 kb slow skeletal muscle mRNA, and its expression was down-regulated during further development.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Acid Sequence
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Animals
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Base Sequence
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Cattle
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Child
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Cloning, Molecular
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DNA / genetics
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DNA / isolation & purification
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DNA Probes
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Fetal Heart / metabolism
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Gene Expression
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Humans
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Molecular Sequence Data
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Myocardium / metabolism*
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RNA, Messenger / metabolism
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Rabbits
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Rats
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Sheep
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Troponin / genetics*
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Troponin / metabolism*
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Troponin T
Substances
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DNA Probes
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RNA, Messenger
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Troponin
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Troponin T
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DNA