Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties

S Kato; K Shindo; H Kawai; A Odagawa; M Matsuoka; J Mochizuki

doi:10.7164/antibiotics.46.892

Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties

J Antibiot (Tokyo). 1993 Jun;46(6):892-9. doi: 10.7164/antibiotics.46.892.

Authors

S Kato¹, K Shindo, H Kawai, A Odagawa, M Matsuoka, J Mochizuki

Affiliation

¹ Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.

PMID: 8344870
DOI: 10.7164/antibiotics.46.892

Abstract

Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.

MeSH terms

Animals
Brain / drug effects
Brain / metabolism
Fermentation
Hypoxia / prevention & control
Lipid Peroxidation / drug effects*
Male
Mice
Proline / analogs & derivatives*
Proline / chemistry
Proline / isolation & purification
Proline / pharmacology
Pyrroles / chemistry
Pyrroles / isolation & purification*
Pyrroles / pharmacology*
Rats
Rats, Wistar
Streptomyces / chemistry*

Substances

Pyrroles
pyrrolostatin
Proline