Abstract
1. A lectin has been purified from the mushroom Boletus satanas Lenz. 2. The protein, called bolesatine, is mitogenic for human T lymphocytes in a dose- and time-dependent manner. 3. Optimal mitogenic doses induce the release of interleukin-1 alpha and interleukin-2 from mononuclear cell cultures.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocytes / cytology
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B-Lymphocytes / drug effects*
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B-Lymphocytes / immunology
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Cell Division / drug effects
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Cells, Cultured
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Centrifugation, Density Gradient
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Fungal Proteins / chemistry
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Fungal Proteins / isolation & purification
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Fungal Proteins / pharmacology*
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Humans
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Interleukin-1 / metabolism
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Interleukin-2 / metabolism
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Lectins / pharmacology*
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Lymphocyte Activation / drug effects*
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Mitogens / pharmacology*
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Mycotoxins*
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Sheep
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T-Lymphocytes / cytology
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T-Lymphocytes / drug effects*
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T-Lymphocytes / immunology
Substances
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Fungal Proteins
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Interleukin-1
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Interleukin-2
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Lectins
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Mitogens
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Mycotoxins
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Bolesatine protein, Boletus satanas