Abstract
This report describes the case of a minimally differentiated acute myeloid leukemia (FAB M0) diagnosed in a 55-year-old woman. During a second chemotherapy-induced complete remission, a subcutaneous nodule appeared at the scar of a recently removed Hickman catheter, which when biopsied revealed leukemic infiltration of the dermis and hypodermis. The patient had a bone marrow relapse three weeks later. The authors review similar recent reports and emphasize the importance of recognizing this particular type of cutaneous leukemic relapse.
MeSH terms
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Acute Disease
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Amsacrine / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor
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Bone Marrow / pathology
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Catheterization, Central Venous / adverse effects*
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Cyclophosphamide / administration & dosage
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Cytarabine / administration & dosage
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Daunorubicin / administration & dosage
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Etoposide / administration & dosage
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Female
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Humans
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Leukemia, Myeloid / drug therapy
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Leukemia, Myeloid / pathology*
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Leukemic Infiltration
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Middle Aged
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Mitoxantrone / administration & dosage
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Neoplasm Seeding*
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Prednisolone / administration & dosage
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Remission Induction
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Salvage Therapy
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Skin / pathology*
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Vindesine / administration & dosage
Substances
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Biomarkers, Tumor
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Amsacrine
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Cytarabine
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Etoposide
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Cyclophosphamide
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Prednisolone
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Mitoxantrone
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Vindesine
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Daunorubicin