Position of cyclization in cyclic ADP-ribose

Biochem Biophys Res Commun. 1993 Aug 16;194(3):1143-7. doi: 10.1006/bbrc.1993.1941.

Abstract

Cyclic adenosine diphosphoribose (cADPR) is a putative second messenger of calcium homeostasis synthesized from NAD by cleavage of the nicotinamide-ribose bond and cyclization of the ribose to the adenine ring. In this study, the ultraviolet absorption spectra of cADPR have been studied as a function of pH and compared to other compounds containing an adenine ring with substitutions at known positions. The results support a structure for cADPR in which cyclization is to position 1 of the adenine ring, rather than to N6, as has been previously proposed.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenine / analogs & derivatives
  • Adenosine / analogs & derivatives
  • Adenosine Diphosphate Ribose / analogs & derivatives*
  • Adenosine Diphosphate Ribose / chemistry
  • Cyclic ADP-Ribose
  • Hydrogen-Ion Concentration
  • Models, Chemical
  • Spectrophotometry, Ultraviolet

Substances

  • Cyclic ADP-Ribose
  • Adenosine Diphosphate Ribose
  • Adenine
  • Adenosine