Acute myeloid leukemia among petrol station attendants

Arch Environ Health. 1993 Jul-Aug;48(4):255-9. doi: 10.1080/00039896.1993.9940369.

Abstract

The risk of acute myeloid leukemia (AML) within different occupations was studied, using occupational information obtained from the Swedish 1970 census. Follow-up in the Swedish Cancer Register was carried out from 1971 to 1984. Among male petrol station attendants, 10 cases were observed versus 2.8 expected (observed/expected = 3.6, 95% confidence interval 1.7-6.6). For several decades, Swedish petrol has contained 3-5% of benzene. Thus, a hypothesis was that benzene had contributed to the excess risk. The work histories of the 10 cases were reconstructed through interviews with surviving relatives and were compatible with the hypothesis. However, because the air benzene exposures at petrol stations always have been lower than benzene exposures associated previously with an increased risk of AML, the leukemogenic effect of benzene may have been potentiated by other petrol or vehicle exhaust components.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Air Pollutants, Occupational / adverse effects*
  • Air Pollutants, Occupational / analysis
  • Benzene / adverse effects*
  • Benzene / analysis
  • Confidence Intervals
  • Environmental Monitoring
  • Epidemiological Monitoring
  • Gasoline / adverse effects*
  • Gasoline / analysis
  • Humans
  • Leukemia, Myeloid, Acute / chemically induced
  • Leukemia, Myeloid, Acute / epidemiology*
  • Leukemia, Myeloid, Acute / pathology
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced
  • Occupational Diseases / epidemiology*
  • Occupational Diseases / pathology
  • Population Surveillance*
  • Risk Factors
  • Sweden / epidemiology

Substances

  • Air Pollutants, Occupational
  • Gasoline
  • Benzene