Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11

J Med Chem. 1993 Aug 6;36(16):2420-3. doi: 10.1021/jm00068a022.
No abstract available

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / chemistry*
  • Animals
  • Blood Pressure / drug effects*
  • Neprilysin / antagonists & inhibitors
  • Neprilysin / chemistry*
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / pharmacology
  • Protein Conformation
  • Rats
  • Rats, Inbred SHR
  • Structure-Activity Relationship
  • Sympathomimetics / analogs & derivatives
  • Sympathomimetics / chemical synthesis*
  • Sympathomimetics / pharmacology

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Oligopeptides
  • Sympathomimetics
  • Neprilysin