Abstract
A synthetic peptide, corresponding to the sequence (637-666) of the HIV-1 glycoprotein gp41, inhibited the replication of an array of HIV-1 strains. The peptide (637-666) selectively binds to the fusion domain at the N-terminus of gp41, suggesting that inhibition of HIV-1 infection is caused by blocking fusion of HIV-1 with cells or of infected cells with uninfected cells. Since this peptide has antiviral activity against both homologous and heterologous HIV-1 isolates and has no detectable cytotoxicity, it offers a novel approach to chemotherapy and prophylaxis of AIDS.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Binding Sites
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Cell Line
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Gene Products, env / metabolism
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HIV Envelope Protein gp160
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HIV Envelope Protein gp41 / metabolism*
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HIV-1 / drug effects
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HIV-1 / metabolism
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HIV-1 / physiology*
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Humans
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Immune Sera / pharmacology
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Molecular Sequence Data
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Peptide Fragments / chemical synthesis
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Peptide Fragments / metabolism
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Peptide Fragments / pharmacology*
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Peptides / chemical synthesis
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Peptides / metabolism
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Peptides / pharmacology*
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Protein Precursors / metabolism
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Virus Replication / drug effects*
Substances
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Gene Products, env
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HIV Envelope Protein gp160
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HIV Envelope Protein gp41
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Immune Sera
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Peptide Fragments
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Peptides
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Protein Precursors