Abstract
More than 90% of cats immunized with inactivated whole infected-cell or cell-free feline immunodeficiency virus (FIV) vaccines were protected against intraperitoneal infection with 10 50% animal infectious doses of either homologous FIV Petaluma (28 of 30 cats) or heterologous FIV Dixon strain (27 of 28 cats). All 15 control cats were readily infected with either strain of FIV. Protection appears to correlate with antiviral envelope antibody levels by a mechanism yet to be determined.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / blood
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Cats
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Immunodeficiency Virus, Feline / immunology*
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Immunodeficiency Virus, Feline / isolation & purification
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Lentivirus Infections / immunology
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Lentivirus Infections / prevention & control*
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Lentivirus Infections / veterinary*
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Specific Pathogen-Free Organisms
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Vaccination*
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Vaccines, Inactivated / therapeutic use*
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Viral Envelope Proteins / immunology
Substances
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Antibodies, Viral
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Vaccines, Inactivated
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Viral Envelope Proteins