Abstract
Phenotypic, genotypic, and karyotypic analyses have indicated that Hodgkin's disease and CD30+ anaplastic large cell lymphoma may be conceived as malignancies derived from activated, cytokine-producing lymphoid cells, in many instances with an immature genotype. Most recently, Epstein-Barr virus (EBV) genomes and gene products, most notably the transformation-associated latent membrane protein (LMP), have been detected in approximately 50 and 20% of the cases, respectively. These findings suggest that EBV may superimpose an activated phenotype on an immature lymphoid cell, contributing to the pathoetiology of sizable proportions of these CD30+ malignancies.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Antigens, CD / analysis*
-
Antigens, Neoplasm / analysis*
-
Chromosome Aberrations*
-
Cytokines / genetics
-
Female
-
Gene Expression
-
Gene Rearrangement
-
Genes, Immunoglobulin
-
Genome, Viral
-
Herpesvirus 4, Human / genetics*
-
Herpesvirus 4, Human / isolation & purification
-
Hodgkin Disease / genetics*
-
Hodgkin Disease / immunology*
-
Hodgkin Disease / microbiology
-
Humans
-
Karyotyping
-
Ki-1 Antigen
-
Lymphoma, Large B-Cell, Diffuse / genetics*
-
Lymphoma, Large B-Cell, Diffuse / immunology*
-
Lymphoma, Large B-Cell, Diffuse / microbiology
-
Male
-
Oncogenes*
-
Proto-Oncogenes*
-
Receptors, Antigen / genetics
Substances
-
Antigens, CD
-
Antigens, Neoplasm
-
Cytokines
-
Ki-1 Antigen
-
Receptors, Antigen