Hepatitis C virus antibodies in acute and chronic liver disease in India

J Hepatol. 1993 Feb;17(2):175-9. doi: 10.1016/s0168-8278(05)80034-0.

Abstract

The prevalence of serum antibodies to hepatitis C virus was assessed by an enzyme-linked immunosorbent assay in patients with epidemic non-A, non-B hepatitis (14), sporadic non-A, non-B hepatitis (42), chronic hepatitis (14) and cirrhosis (26). None of the patients with epidemic non-A, non-B hepatitis (14) and acute self-limiting sporadic non-A, non-B hepatitis without prior parenteral exposure (38) tested positive for hepatitis C virus antibody. Based on epidemiologic features, hepatitis E virus is presumably the etiologic agent for both these entities. Hepatitis C virus (HCV) antibody was positive in none of the patients with cryptogenic chronic hepatitis (11) and in 2(8%) patients with cryptogenic cirrhosis (25). It was concluded that cryptogenic chronic hepatitis and cirrhosis in India may be caused by alternative viral agents of the non-A, non-B type or by hepatotoxins to which the population may be exposed. Of 8 patients with prior parenteral exposure (transfusions 6, needle pricks 2) 5 (62.5%) patients tested positive for HCV antibody. HCV antibody was detected in 1 (25%) patient with acute self-limiting, parenterally transmitted non-A, non-B hepatitis and in 4 (100%) patients with chronic parenterally transmitted non-A, non-B hepatitis.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Chronic Disease
  • Female
  • Hepacivirus / isolation & purification*
  • Hepatitis Antibodies / blood*
  • Hepatitis C / microbiology
  • Hepatitis E / microbiology
  • Hepatitis, Viral, Human / microbiology
  • Humans
  • India / epidemiology
  • Liver Cirrhosis / microbiology
  • Liver Diseases / microbiology*
  • Male
  • Prevalence

Substances

  • Hepatitis Antibodies