Abstract
We determined the acyclovir (ACV) susceptibilities of herpes simplex virus (HSV) isolates (n = 18) recovered from solid organ transplant patients after antiviral prophylaxis with ACV or ganciclovir. All isolates tested were susceptible to ACV (50% inhibitory concentration, < 1 microM). A clinical review of patients with HSV disease showed that all improved with specific anti-HSV therapy, and no recurrences were reported.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acyclovir / pharmacology*
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Acyclovir / therapeutic use
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Cytomegalovirus Infections / prevention & control
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Drug Resistance, Microbial
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Ganciclovir / therapeutic use*
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Herpes Simplex / prevention & control
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Humans
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Simplexvirus / drug effects*
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Simplexvirus / genetics
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Transplantation, Homologous / physiology*
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Viral Plaque Assay