Abstract
This paper reviews the therapeutics of migraine in the context of the clinical problem and its prevalence. General principles of pharmacotherapy for symptomatic and preventive medications are provided. Two new drugs, sumatriptan (recommended for acute symptomatic therapy), and valproic acid (recommended for migraine prevention), are reviewed. The clinical effectiveness and the mechanisms of action of these drugs are discussed.
MeSH terms
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Brain / blood supply
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Humans
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Indoles / adverse effects
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Indoles / therapeutic use*
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Migraine Disorders / drug therapy*
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Neurons / drug effects
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Serotonin Receptor Agonists / adverse effects
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Serotonin Receptor Agonists / therapeutic use*
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Sulfonamides / adverse effects
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Sulfonamides / therapeutic use*
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Sumatriptan
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Valproic Acid / adverse effects
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Valproic Acid / therapeutic use*
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Vasoconstriction / drug effects
Substances
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Indoles
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Serotonin Receptor Agonists
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Sulfonamides
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Valproic Acid
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Sumatriptan